Wayne Delport is a bioinformatics and genomics technology leader with more than two decades of experience building scalable computational biology platforms and advancing precision medicine. As Co-Founder and CTO of Simplify Genomics, he leads the development of AI-driven genomic interpretation and search technologies designed to accelerate clinical decision-making and make whole genome data actionable in healthcare. Wayne has authored widely cited research in evolutionary biology, genomics, and computational methods, with thousands of academic citations across his work. His expertise spans cloud-based bioinformatics systems, genomic data infrastructure, and translating complex biological data into practical clinical applications.
Artificial intelligence is rapidly transforming genomics, making powerful analytical tools accessible to more people than ever before. But while AI can generate convincing interpretations, it does not replace the deep expertise required to evaluate genetic evidence, recognize uncertainty, and make… Read More »AI Democratizes the Appearance of Expertise. In Genomics, That’s a Problem
Simplify Genomics today announced a collaboration with SimonMed aimed at advancing a more integrated approach to preventive healthcare. By combining SimonMed’s national scale in whole-body MRI with Simplify’s Whole Genome Interpretation and Reporting Platform, the collaboration seeks to provide a more complete picture of human health— helping identify risk earlier, personalize… Read More »Simplify Genomics and SimonMed Announce Collaboration to Advance Preventive Healthcare Through Integrated Genomics and Imaging
Polygenic Risk Scores (PRS) have emerged as one of the most promising tools in genomic medicine, offering insights into an individual’s inherited predisposition to common complex diseases. By combining the effects of thousands—or even millions—of genetic variants across the genome,… Read More »Polygenic Risk Scores: How We Evaluate Genetic Risk Models
What Consumers Should Know About Genomic Testing In this article, Wayne Delport challenges the common assumption that clinical-grade sequencing automatically represents the highest standard in genomic testing. The piece explores the technical, analytical, and regulatory differences between clinical sequencing pipelines… Read More »Clinical-Grade Sequencing Isn’t the Gold Standard
A Genomics Reporting Problem Patients Should Understand In this article, Wayne Delport examines a critical issue in consumer genomics and clinical genetic reporting: the omission of Factor V Leiden status from reports that reference “Factor V”–related clotting risk. Using real-world… Read More »When Factor V Doesn’t Include Leiden
In this article, Wayne Delport examines one of the most widely misunderstood concepts in genetics: heritability. The piece explains why heritability estimates are frequently misinterpreted as direct measures of genetic determinism, when in reality they describe how variation within a… Read More »Heritability: The Persistent Misinterpretation
Where Polygenic Risk-Based Estimates of Absolute Risk Start To Fail In this second article of this series, Wayne Delport explores the statistical limits of polygenic risk scores (PRS) and why extreme estimates of absolute disease risk often become unreliable at… Read More »PRS: Breaking the Tails
Why That Number Is Probably Misleading In this article, Wayne Delport examines how polygenic risk scores (PRS) can sometimes generate misleading interpretations of disease risk — particularly for Type 2 Diabetes. Using a genetic report that suggested an “89% lifetime… Read More »Genetic Report says 89% Risk of T2D
The Accreditation Committee of the College of American Pathologists (CAP) has awarded accreditation to Simplify Genomics, San Diego, CA, based on the results of a recent on-site inspection as part of the CAP’s Accreditation Programs. Recognized for rigorous and robust standards, CAP… Read More »Simplify Genomics receives accreditation from the College of American Pathologists
San Diego, Ca., 01.25.24 – Genomics Technology Company, Simplify Genomics, Emerges from Development Mode by leveraging the infrastructure developed at Genomic Sequencing Pioneer Human Longevity with the launch of a Searchable Genome, Interpretation, and Reporting Platform Called Smart Genome. This… Read More »Smart Genome: Simplify Launches Genome Search and Report