
Trusted Clinical Genomics Infrastructure
Smart Genome combines clinical whole genome reporting, genomic interpretation, and large-scale genome exploration in a unified platform for healthcare, research, and precision medicine.
Built on years of clinical reporting experience and validated genomic methodologies, Simplify Genomics helps organizations transform genomic data into clinically meaningful insights and actionable knowledge.
Clinical Genomics Intelligence
Simplify Genomics combines clinical reporting expertise, curated genomic knowledge, and scalable genome intelligence infrastructure to support healthcare, research, and precision medicine programs.
- CLIA-certified and CAP-accredited genomic reporting
- Clinical Whole Genome reporting since 2018
- Hereditary Disease, Polygenic Risk, and pharmacogenomics reporting
- Clinical Decision Support with Genetic Counselor services


Featured Resources
- Simplify Genomics and SimonMed Announce Collaboration to Advance Preventive Healthcare Through Integrated Genomics and ImagingSimplify Genomics today announced a collaboration with SimonMed aimed at advancing a more integrated approach to preventive healthcare. By combining SimonMed’s national scale in whole-body MRI with Simplify’s Whole Genome Interpretation and Reporting Platform, the collaboration seeks to provide a more complete picture of human health— helping identify risk earlier, personalize care pathways, and support more proactive health decisions. Across both imaging and genomics, there is growing… Read More »Simplify Genomics and SimonMed Announce Collaboration to Advance Preventive Healthcare Through Integrated Genomics and Imaging
- Polygenic Risk Scores: How We Evaluate Genetic Risk ModelsPolygenic Risk Scores (PRS) have emerged as one of the most promising tools in genomic medicine, offering insights into an individual’s inherited predisposition to common complex diseases. By combining the effects of thousands—or even millions—of genetic variants across the genome, PRS models can help estimate relative disease risk beyond traditional family history alone. However, not… Read More »Polygenic Risk Scores: How We Evaluate Genetic Risk Models
Genomic Findings
Learn how the Smart GenomeTM platform unifies genomic information in one platform and how our approach can be applied to transform patient care in your organization.


1.6M+ variants interpreted

2000+ genes and 2100+ hereditary disease associations curated

8+ years CLIA-certified and CAP-accredited Whole Genome Sequence reporting

~1.5 Billion queryable variant records

Let’s discuss your needs
We can provision your genomic data in a fast, queryable, secure platform