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# Simplify Genomics

Trusted Clinical Genomics Infrastructure and Reporting

## Sitemaps

- [XML Sitemap](https://simplifygenomics.com/sitemap.xml): Contains all public & indexable URLs for this website.

## Posts

- [Actionability in Genomic Medicine: More Than Choosing the Right Drug](https://simplifygenomics.com/actionability-in-genomic-medicine-more-than-choosing-the-right-drug/) - The concept of actionability in genetics is frequently associated with identifying genetic variants that directly inform therapeutic intervention. In pharmacogenomics, actionability often means using genetic information that may inform treatment selection and dosing for an individual. Cholesterol management is an excellent example. Although low-density lipoprotein (LDL), a lipoprotein particle that carries cholesterol, is often referred to as "bad cholesterol," cholesterol
- [Rethinking Clinical Actionability in Genomics](https://simplifygenomics.com/rethinking-clinical-actionability-in-genomics/) - One question frequently asked is: “How many actionable genes do you report?” While this sounds like a simple question, it is really asking something much broader: “Under what circumstances can genomic information inform patient care?” The true value of genomic testing is not measured by the number of genes labeled as actionable. Instead, it depends on whether a
- [AI Democratizes the Appearance of Expertise. In Genomics, That's a Problem](https://simplifygenomics.com/ai-democratizes-the-appearance-of-expertise-in-genomics-thats-a-problem/) - Artificial intelligence is rapidly transforming genomics, making powerful analytical tools accessible to more people than ever before. But while AI can generate convincing interpretations, it does not replace the deep expertise required to evaluate genetic evidence, recognize uncertainty, and make clinically defensible decisions. In this article, Wayne Delport explores why genetic interpretation is fundamentally different
- [Simplify Genomics and SimonMed Announce Collaboration to Advance Preventive Healthcare Through Integrated Genomics and Imaging](https://simplifygenomics.com/simplify-genomics-and-simonmed-announce-collaboration-to-advance-preventive-healthcare-through-integrated-genomics-and-imaging/) - PDF Simplify Genomics today announced a collaboration with SimonMed aimed at advancing a more integrated approach to preventive healthcare. By combining SimonMed’s national scale in whole-body MRI with Simplify’s Whole Genome Interpretation and Reporting Platform, the collaboration seeks to provide a more complete picture of human health— helping identify risk earlier, personalize care pathways, and support more proactive health decisions. Across both imaging and genomics, there is
- [Polygenic Risk Scores: How We Evaluate Genetic Risk Models](https://simplifygenomics.com/polygenic-risk-score-validation-how-we-evaluate-genetic-risk-models/) - Polygenic Risk Scores (PRS) have emerged as one of the most promising tools in genomic medicine, offering insights into an individual's inherited predisposition to common complex diseases. By combining the effects of thousands—or even millions—of genetic variants across the genome, PRS models can help estimate relative disease risk beyond traditional family history alone. However, not
- [Smart Genome: Simplify Launches Genome Search and Report](https://simplifygenomics.com/smart-genome-launch/) - Simplify Genomics leverages infrastructure developed at Human Longevity and launches a searchable genome and reporting platform called Smart Genome.
- [Simplify Genomics receives accreditation from the College of American Pathologists](https://simplifygenomics.com/cap-accreditation/) - The Accreditation Committee of the College of American Pathologists (CAP) has awarded accreditation to Simplify Genomics, San Diego, CA, based on the results of a recent on-site inspection as part of the CAP’s Accreditation Programs. Recognized for rigorous and robust standards, CAP accreditation elevates quality and mitigates risk, an important way laboratories contribute to improved patient outcomes.
- [Heritability: The Persistent Misinterpretation](https://simplifygenomics.com/the-persistent-misinterpretation-of-heritability/) - In this article, Wayne Delport examines one of the most widely misunderstood concepts in genetics: heritability. The piece explains why heritability estimates are frequently misinterpreted as direct measures of genetic determinism, when in reality they describe how variation within a population is statistically partitioned between genetic and environmental factors under specific conditions. The article explores
- [Genetic Report says 89% Risk of T2D](https://simplifygenomics.com/genetic-report-says-89-risk-of-type-2-diabetes-why-that-number-is-probably-misleading/) - Why That Number Is Probably Misleading In this article, Wayne Delport examines how polygenic risk scores (PRS) can sometimes generate misleading interpretations of disease risk — particularly for Type 2 Diabetes. Using a genetic report that suggested an “89% lifetime risk” result as a real-world example, the article explains the difference between relative risk and
- [PRS: Breaking the Tails](https://simplifygenomics.com/breaking-the-tails/) - Where Polygenic Risk-Based Estimates of Absolute Risk Start To Fail In this second article of this series, Wayne Delport explores the statistical limits of polygenic risk scores (PRS) and why extreme estimates of absolute disease risk often become unreliable at the far ends of the distribution curve. Focusing on the “tails” of polygenic risk modeling,
- [When Factor V Doesn’t Include Leiden](https://simplifygenomics.com/when-factor-v-doesnt-include-factor-v-leiden/) - A Genomics Reporting Problem Patients Should Understand In this article, Wayne Delport examines a critical issue in consumer genomics and clinical genetic reporting: the omission of Factor V Leiden status from reports that reference “Factor V”–related clotting risk. Using real-world examples, the article highlights how incomplete or ambiguous reporting can mislead patients and create false
- [Clinical-Grade Sequencing Isn’t the Gold Standard](https://simplifygenomics.com/clinical-grade-sequencing-isnt-the-gold-standard/) - What Consumers Should Know About Genomic Testing In this article, Wayne Delport challenges the common assumption that clinical-grade sequencing automatically represents the highest standard in genomic testing. The piece explores the technical, analytical, and regulatory differences between clinical sequencing pipelines and modern high-resolution consumer genomics platforms, highlighting how the term “clinical-grade” is often used inconsistently

## Pages

- [Home](https://simplifygenomics.com/) - Trusted Clinical Genomics Infrastructure Smart Genome combines clinical whole genome reporting, genomic interpretation, and large-scale genome exploration in a unified platform for healthcare, research, and precision medicine. Built on years of clinical reporting experience and validated genomic methodologies, Simplify Genomics helps organizations transform genomic data into clinically meaningful insights and actionable knowledge. LEARN MORE CONTACT
- [Media](https://simplifygenomics.com/media/) - Media In the News July 2, 2026 Simply Genomics, SimonMed Strike Personalized Healthcare Alliance June 30, 2026 Simplify Genomics and SimonMed Announce Collaboration to Advance Preventive Healthcare Through Integrated Genomics and Imaging June 29, 2026 SimonMed, Simplify Genomics collaborate on preventive health February 29, 2024 Simplify Genomics Eyes Preventative Testing Market With Automated Genome Reporting
- [About](https://simplifygenomics.com/company/about/) - At Simplify Genomics, our purpose is to deliver genomics innovation across all healthcare landscapes: clinical, biotechnology, and pharmaceutical.
- [Smart Genome](https://simplifygenomics.com/platform/) - Review our powerful and fast genome exploration platform and whole genome CLIA-certified and CAP-accredited clinical reporting
- [Team](https://simplifygenomics.com/company/team/) - The Team Behind Clinical Genomics Intelligence Built on a Foundation of Genomics Innovation Simplify Genomics was formed by a team of scientists, engineers, and healthcare innovators with experience developing large-scale genomic reporting and interpretation systems. Our work builds on years of clinical reporting, genomic analysis, and precision medicine initiatives designed to make genomic information more
- [History](https://simplifygenomics.com/company/history/) - Track the history of Simplify Genomics back to 2013, detailing how we've worked to develop genomic medicine and make it readily available in all of healthcare.
- [Blog](https://simplifygenomics.com/media/blog/) - Blog
- [Company](https://simplifygenomics.com/company/) - The Clinical Genomics Intelligence Company Empower Genomics Simplify Genomics, Inc. is a genomics technology company that has built an analytical and interpretation platform to empower genomics in healthcare. This vision is motivated by the observation that genomics is still not central to primary care more than 20 years after the completion of the first draft
- [Privacy](https://simplifygenomics.com/privacy/) - Review details of how we collect and use your data to improve services hosted at our website.
- [Our Findings](https://simplifygenomics.com/findings/) - Simplify Genomics’ clinical whole genome reporting solutions provide medical experts with certified clinical reports to allow for medical care at maximum precision.
- [Open Search](https://simplifygenomics.com/opensearch/) - Simplify Genomics provides access to 10,000 genomes sequenced at Human Longevity in a browser-based application to support genomics R&D.
- [FAQ](https://simplifygenomics.com/faq/) - Find answers to the most common questions about Simplify Genomics, genome sequencing, whole genome reporting, and more.
- [Contact](https://simplifygenomics.com/contact/) - Get in touch with us at Simplify Genomics today to learn about the Smart Genome difference. We can't wait to hear from you!

## Timeline Stories

- [Simplify Genomics, Inc. closes community raise](https://simplifygenomics.com/cool_timeline/simplify-genomics-inc-closes-community-raise/) - Closed a fully subscribed $5 million Wefunder round, validating market demand for our genomic intelligence platform and providing capital to scale commercialization and product development.
- [Simplify Genomics launches 9th major release of Genomic Report](https://simplifygenomics.com/cool_timeline/simplify-genomics-launches-9th-major-release-of-genomic-report/) - Simplify Genomics, Inc. releases its 9th major revision of the Genomic Clinical Report, significantly expanding the scope of pharmacogenomic genes and drug associations.
- [Simplify Genomics emerges from Stealth Mode](https://simplifygenomics.com/cool_timeline/simplify-genomics-emerges-from-stealth-mode/) - Genomics Technology Company, Simplify Genomics, Emerges from Development Mode by leveraging the infrastructure developed at Genomic Sequencing Pioneer Human Longevity with the launch of a Searchable Genome, Interpretation, and Reporting Platform Called Smart GenomeTM.
- [Simplify Genomics Launches Genome Search Engine](https://simplifygenomics.com/cool_timeline/simplify-genomics-launches-genome-search-engine/) - Simplify Genomics, Inc. relaunches a beta genome search engine and reduces hosting costs by 95%. The genome search engine allows clinicians to explore complete genomes with a user-friendly interface that can query hundreds of millions of genomic variants at the speed of thought.
- [Simplify Genomics establishes SAB with Dr Richard Cote](https://simplifygenomics.com/cool_timeline/simplify-genomics-add-dr-richard-cote-to-sab/) - Simplify Genomics, Inc., a genomics-technology company, establishes its Scientific Advisory Board with Dr. Richard Cote, Chair of Pathology and Immunology at Washington University. With the addition of Dr. Cote, Simplify Genomics gains deep expertise in clinical pathology and in the biotechnology industry, as both founder and advisor to numerous biotechnology and pharmaceutical companies operating at
- [Simplify Genomics Inc is launched](https://simplifygenomics.com/cool_timeline/hli-divests-genomics-business/) - Human Longevity, Inc. spins out the genomics reporting and research division to form a new company, Simplify Genomics, Inc. Simplify Genomics migrates genomics data, workflows, and supporting infrastructure to establish independent operations for clinical Whole Genome Sequencing and R&D.
- [HLI adds polygenic risk to WGS reports](https://simplifygenomics.com/cool_timeline/hli-includes-polygenic-risk-in-clinical-reporting/) - Human Longevity Clinical Laboratories, LLC validates polygenic risk models for common diseases for inclusion in the 5th major release of CLIA-verified and CAP-accredited Whole Genome Report. Details on validation are published in a white paper and presented at ASHG 2020.
- [HLI sells Oncology Division to Neo Genomics](https://simplifygenomics.com/cool_timeline/hli-oncology-division-sold-to-neo-genomics/) - Human Longevity, Inc. sells its Oncology division to Neo Genomics, narrowing its focus on longevity and extending the human lifespan using a multi-modal approach to disease risk and management.
- [HLI launches Clinical Genome Report](https://simplifygenomics.com/cool_timeline/hli-launches-clinical-genome-report/) - HLI launches CLIA-verified and CAP-accredited Whole Genome report for clinical screening.
- [HLI receives CAP accreditation](https://simplifygenomics.com/cool_timeline/hli-launches-clinical-whole-genome-product/) - Human Longevity, Inc. laboratory (Human Longevity Clinical Laboratory, LLC) receives accreditation from the College of American Pathologists.
- [HLI receives CLIA certification](https://simplifygenomics.com/cool_timeline/hli-receives-clia-certification/) - Human Longevity, Inc. (HLI), the genomic-driven health information technology company, announces that the company has received certification under the Clinical Laboratory Improvement Amendments of 1988 (CLIA).
- [HLI streamlines variant interpretation](https://simplifygenomics.com/cool_timeline/hli-streamlines-variant-interpretation/) - Human Longevity, Inc. develops a novel approach for streamlining germline variant interpretation in accordance with industry standards.
- [HLI completes sequencing of 10K genomes](https://simplifygenomics.com/cool_timeline/hli-publishes-10k-genomes-paper/) - Human Longevity, Inc. completes the sequencing of 10,545 whole genomes at 30-40x coverage. This deep analysis of the human genome demonstrates that up to 84% of a human genome can be deep sequenced with the specificity and precision required for clinical use. De-identified data is made available to researchers through Open Search.
- [HLI acquires Cypher Genomics](https://simplifygenomics.com/cool_timeline/hli-acquires-cypher-genomics/) - HLI acquires Cypher Genomics informatics company founded by Ashley Van Zeeland, Ali Torkamani, Nicholas Schork, and Eric Topol.
- [HLI raises $220 Million](https://simplifygenomics.com/cool_timeline/hli-raises-220-million/) - Human Longevity, Inc. raises $220 million in a Series B led by Celgene and Illumina.
- [Human Longevity, Inc Launch](https://simplifygenomics.com/cool_timeline/human-longevity-inc-launched/) - J. Craig Venter, Peter Diamandis, and Robert J. Hariri launch Human Longevity Inc. with the aim of enabling predictive and preventative medicine for healthy aging and discovering early warning signs for susceptibility to chronic illness.
- [HLI publishes study on early detection of disease](https://simplifygenomics.com/cool_timeline/hli-publishes-study-on-early-detection-of-disease/) - Human Longevity, Inc. publishes a study in the Proceedings of the National Academy of Sciences demonstrating that the integration of whole-genome sequencing with advanced imaging and blood metabolites, allows clinicians to identify adults at risk for key health conditions.
- [First Draft of the Human Genome](https://simplifygenomics.com/cool_timeline/first-draft-of-the-human-genome/) - J. Craig Venter and Francis Collins jointly announce the first draft of the Human Genome, published in Science and Nature.
- [HLI Signs Agreement with Genentech](https://simplifygenomics.com/cool_timeline/human-longevity-inc-signs-agreement-with-genentech/) - Human Longevity, Inc. signs a multi-year agreement with Genentech to conduct Whole Genome Sequencing and analysis of tens of thousands of samples.
- [HLI launches Health Nucleus](https://simplifygenomics.com/cool_timeline/hli-launched-health-nucleus/) - Human Longevity, Inc. launches the Health Nucleus platform that uses whole genome sequencing, advanced clinical imaging, and innovative machine learning – combined with a comprehensive curation of personal health history – to deliver the most complete picture of individual health.
- [HLI and MassMutual sign multi-year agreement](https://simplifygenomics.com/cool_timeline/hli-and-massmutual-sign-multi-year-agreement/) - Human Longevity, Inc. and Massachusetts Mutual Life Insurance Co. announce a multi-year agreement to offer HLI's whole genome sequencing product to MassMutual customers, employees, and financial professionals.
- [HLI closes $30 Million Financing](https://simplifygenomics.com/cool_timeline/hli-closes-30-million-financing/) - Human Longevity, Inc. announces a $30 million financing led by Emerging Technology Partners, LLC. Proceeds from the financing are to be used to enhance the Health Nucleus Platform.
- [Simplify Genomics launches 8th major release of Genomic Report](https://simplifygenomics.com/cool_timeline/simplify-genomics-launches-8th-major-clinical-genomic-report/) - Simplify Genomics, Inc. releases its 8th major revision of the Genomic Clinical Report, significantly increasing the scope of gene-disease associations covered.

## Categories

- [Press](https://simplifygenomics.com/category/press/)
- [Blog](https://simplifygenomics.com/category/blog/)
- [Whitepapers](https://simplifygenomics.com/category/whitepapers/)

## Tags

- [press](https://simplifygenomics.com/tag/press/)
- [polygenic risk](https://simplifygenomics.com/tag/polygenic-risk/)